Weirton, city, Hancock and Brooke counties, northwestern West Virginia, on the Ohio River; incorporated 1947. It is a major steel-producing center situated in a coal- and clay-mining region. Other manufactures include metal products, building materials, chemicals, and lubricants. A community college is here. The area was settled in the late 18th century. In 1909-10 Ernest T. Weir established an integrated steel plant here, and the settlement, named in his honor, grew as an industrial center. Population 25,371 (1980); 22,124 (1990); 20,411 (2000).