Cayey, town, in Cayey Municipality, southwestern Puerto Rico, in the Sierra de Cayey. Situated in a tobacco-growing region, Cayey is known for the manufacture of cigars. Clothing also is produced, and the town has a substantial tourist industry. Cayey University College (1967) is there, and Henry Barracks, a U.S. military facility, is nearby. The community was founded as Cayey de Muesas by the Spanish in 1774. Population (1990) 23,332.