My Tho, city, southern Vietnam, capital of Tien Giang Province, an inland port in the Mekong River Delta. It is a transportation and commercial center for a rich agricultural region and has some manufacturing industries. My Tho was controlled by the Cambodians until it was annexed by the Annamese in the late 17th century. It was under French rule from 1862 to 1954. Population (1989) 104,848.